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bioRxiv · 10.1101/2021.03.05.434159

Feedback ratiometric control of two microbial populations in a single chemostat

Fiore, D.·Della Rossa, F.·Guarino, A.·di Bernardo, M.
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Abstract

We address the problem of controlling the dilution rate in a chemostat to regulate the ratio between the concentrations of two microbial populations growing in continuous culture. After analyzing the open-loop dynamics of this multicellular system, we present two alternative feedback control strategies, one based on a gain-scheduled state feedback controller, the other on a switching control strategy. We show that both strategies are effective in solving the problem and illustrate the results by a set of representative numerical simulation.

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Fiore, D., Della Rossa, F., Guarino, A., di Bernardo, M.. 2021-03-06. Feedback ratiometric control of two microbial populations in a single chemostat. https://doi.org/10.1101/2021.03.05.434159

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