Periodic synchronization of dengue epidemics in Thailand: the roles played by temperature and immunity

Garcia-Carreras, B.; Yang, B.; Grabowski, M. K.; Sheppard, L. W.; Huang, A. T.; Salje, H.; Clapham, H. E.; Iamsirithaworn, S.; Doung-Ngern, P.; Lessler, J.; Cummings, D. A. T.

doi:10.1101/2021.03.01.433325

bioRxiv · 10.1101/2021.03.01.433325

Periodic synchronization of dengue epidemics in Thailand: the roles played by temperature and immunity

Garcia-Carreras, B.·Yang, B.·Grabowski, M. K.·Sheppard, L. W.·Huang, A. T.·Salje, H.·Clapham, H. E.·Iamsirithaworn, S.·Doung-Ngern, P.·Lessler, J.·Cummings, D. A. T.

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Abstract

The spatial distribution of dengue and its vectors (spp. Aedes) may be the widest it has ever been, and projections suggest that climate change may allow the expansion to continue. However, the largest impacts of climate change on dengue might be in regions where the pathogen is already endemic. In these areas, the waxing and waning of immunity has a large impact on temporal dynamics of cases of dengue haemorrhagic fever. Here, we use 51 years of data across 72 provinces and characterise spatio-temporal patterns of dengue in Thailand, where dengue has caused almost 1.5 million cases over the last thirty years, and examine the roles played by temperature and dynamics of immunity in giving rise to those patterns. We find that timescales of multiannual oscillations in dengue vary in space and time and uncover an interesting spatial phenomenon: Thailand has experienced multiple, periodic synchronization events. We show that patterns in synchrony of dengue are consistent with those observed in temperature. Applying a temperature-driven dengue model, we explore how dynamics of immunity interact with temperature to produce the observed multiannual dynamics and patterns in synchrony. While multiannual oscillations are readily produced by immunity in absence of multiannual timescales in temperature, synchrony in temperature can synchronise dengue dynamics in different locations. However, at higher mean temperatures and lower seasonal variation, immune dynamics become more predominant, and dengue dynamics become more insensitive to multiannual fluctuations in temperature. These findings can help underpin predictions of disease patterns as global temperatures rise. Author summary

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Garcia-Carreras, B., Yang, B., Grabowski, M. K., Sheppard, L. W., Huang, A. T., Salje, H., Clapham, H. E., Iamsirithaworn, S., Doung-Ngern, P., Lessler, J., Cummings, D. A. T.. 2021-03-01. Periodic synchronization of dengue epidemics in Thailand: the roles played by temperature and immunity. https://doi.org/10.1101/2021.03.01.433325

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