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bioRxiv · 10.1101/2021.02.08.430294

Simultaneous functional MRI of socially interacting marmosets

Gilbert, K. M.·Clery, J. C.·Gati, J. S.·Hori, Y.·Mashkovtsev, A.·Zeman, P.·Menon, R. S.·Schaeffer, D. J.·Everling, S.
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Abstract

Social cognition is a dynamic process that requires the perception and integration of a complex set of idiosyncratic features between interacting conspecifics. Here we present a method for simultaneously measuring the whole-brain activation of two socially interacting marmoset monkeys using functional magnetic resonance imaging. MRI hardware (a radiofrequency coil and peripheral devices) and image-processing pipelines were developed to assess brain responses to socialization, both on an intra-brain and inter-brain level. Notably, brain-activation maps acquired during constant interaction demonstrated neuronal synchrony between marmosets in regions of the brain responsible for processing social interaction. This method enables a wide range of possibilities for studying social function and dysfunction in a non-human primate model, including using transgenic models of neuropsychiatric disorders.

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Gilbert, K. M., Clery, J. C., Gati, J. S., Hori, Y., Mashkovtsev, A., Zeman, P., Menon, R. S., Schaeffer, D. J., Everling, S.. 2021-02-08. Simultaneous functional MRI of socially interacting marmosets. https://doi.org/10.1101/2021.02.08.430294

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