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bioRxiv · 10.1101/2021.02.01.428496

Hierarchical modelling of functional brain networks in population and individuals from big fMRI data

Abstract

A major goal of large-scale brain imaging datasets is to provide resources for investigating heterogeneous populations. Characterisation of functional brain networks for individual subjects from these datasets will have an enormous potential for prediction of cognitive or clinical traits. We propose for the first time a technique, Stochastic Probabilistic Functional Modes (sPROFUMO), that is scalable to UK Biobank (UKB) with expected 100,000 participants, and hierarchically estimates functional brain networks in individuals and the population, while allowing for bidirectional flow of information between the two. Using simulations, we show the models utility, especially in scenarios that involve significant cross-subject variability, or require delineation of fine-grained differences between the networks. Subsequently, by applying the model to resting-state fMRI from 4999 UKB subjects, we mapped resting state networks (RSNs) in single subjects with greater detail than has been possible previously in UKB (>100 RSNs), and demonstrate that these RSNs can predict a range of sensorimotor and higher-level cognitive functions. Furthermore, we demonstrate several advantages of the model over independent component analysis combined with dual-regression (ICA-DR), particularly with respect to the estimation of the spatial configuration of the RSNs and the predictive power for cognitive traits. The proposed model and results can open a new door for future investigations into individualised profiles of brain function from big data. HighlightsO_LIWe introduce stochastic PROFUMO (sPROFUMO) for inferring functional brain networks from big data C_LIO_LIsPROFUMO hierarchically estimates fMRI networks for the population and every individual C_LIO_LIWe characterised high dimensional resting state fMRI networks from UK Biobank C_LIO_LIModel outperforms ICA and dual regression for estimation of individual-specific network topography C_LIO_LIWe demonstrate the models utility for predicting cognitive traits, and capturing subject variability in network topographies versus connectivity C_LI

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BibTeXRIS

Farahibozorg, S.-R., Bijsterbosch, J. D., Gong, W., Jbabdi, S., Smith, S. M., Harrison, S. J., Woolrich, M. W.. 2021-02-01. Hierarchical modelling of functional brain networks in population and individuals from big fMRI data. https://doi.org/10.1101/2021.02.01.428496

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