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bioRxiv · 10.1101/2021.01.27.428394

Lysosomal-Immune Axis Is Associated with COVID 19 Disease Severity: Insights from Patient Single Cell Data

Pande, R.·Teeple, E.·Huang, W.·Klinger, K. W.·Rajpal, D.·Kumar, D.
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Abstract

SARS-COV-2 has become a leading cause of illness, hospitalizations, and deaths worldwide yet heterogeneity in disease morbidity remains a conundrum. In this study, we analyzed publicly available single-cell RNA-seq data from 75076 cells sequenced from clinically staged COVID-19 patients using a network approach and identified lysosomal-immune axis as a factor significantly associated with disease severity. Our results suggest modulation of lysosomal-immune pathways may present a novel drug-targeting strategy to attenuate SARS-Cov-2 infections.

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Pande, R., Teeple, E., Huang, W., Klinger, K. W., Rajpal, D., Kumar, D.. 2021-01-27. Lysosomal-Immune Axis Is Associated with COVID 19 Disease Severity: Insights from Patient Single Cell Data. https://doi.org/10.1101/2021.01.27.428394

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