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bioRxiv · 10.1101/2021.01.25.428179

Microstructure Aware Modeling Of Biochemical Transport In Arterial Blood Clots

Teeraratkul, C.·Mukherjee, D.
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Abstract

Flow-mediated transport of biochemical species is central to thrombotic phenomena. Comprehensive three-dimensional modeling of flow-mediated transport around realistic macroscale thrombi poses challenges owing to their arbitrary heterogeneous microstructure. Here, we develop a microstructure aware model for species transport within and around a macroscale thrombus by devising a custom preconditioned fictitious domain formulation for thrombus-hemodynamics interactions, and coupling it with a fictitious domain advection-diffusion formulation for transport. Microstructural heterogeneities are accounted through a hybrid discrete particle-continuum approach for the thrombus interior. We present systematic numerical investigations on unsteady arterial flow within and around a three-dimensional macroscale thrombus; demonstrate the formation of coherent flow structures around the thrombus which organize advective transport; illustrate the role of the permeation processes at the thrombus boundary and subsequent intra-thrombus transport; and characterize species transport from bulk flow to the thrombus boundary and vice versa.

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Teeraratkul, C., Mukherjee, D.. 2021-01-27. Microstructure Aware Modeling Of Biochemical Transport In Arterial Blood Clots. https://doi.org/10.1101/2021.01.25.428179

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