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bioRxiv · 10.1101/2021.01.25.428152

The urea cycle is transcriptionally controlled by hypoxia-inducible factors

Singh, C.·Benos, A.·Grenell, A.·Tran, V.·Hanna, D.·Kannekanti, N.·Anand-Apte, B.·Brunengraber, H.·Sears, J.
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Abstract

Here, we demonstrate transcriptional regulation of urea cycle genes CPS1 and ARG1 by hypoxia-inducible factors (HIFs) and demonstrate a hepatic HIF dependent increase in urea cycle activity.

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Singh, C., Benos, A., Grenell, A., Tran, V., Hanna, D., Kannekanti, N., Anand-Apte, B., Brunengraber, H., Sears, J.. 2021-01-27. The urea cycle is transcriptionally controlled by hypoxia-inducible factors. https://doi.org/10.1101/2021.01.25.428152

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