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bioRxiv · 10.1101/2021.01.16.426973

A sexual dimorphic role of the miR-465 cluster in placental development

Wang, Z.·Meng, N.·Wang, Y.·Zhou, T.·Li, M.·Wang, S.·Chen, S.·Zheng, H.·Kong, S.·Wang, H.·Yan, W.
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Abstract

A sexually dimorphic role of miRNAs in placental development has never been reported. Here, we show that ablation of the miR-465 cluster caused selective degeneration of female conceptuses as early as embryonic day (E)8.5, leading to a male-biased sex ratio (60% males) among miR-465 KO mice. Given that the miR-465 cluster miRNAs were predominantly expressed in the extraembryonic tissue and ablation of these miRNAs led to dysregulation of numerous critical placental genes, our data strongly suggest the miR-465 cluster is required for full developmental potential of the female, but not the male, extraembryonic tissue/placenta.

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Wang, Z., Meng, N., Wang, Y., Zhou, T., Li, M., Wang, S., Chen, S., Zheng, H., Kong, S., Wang, H., Yan, W.. 2021-01-17. A sexual dimorphic role of the miR-465 cluster in placental development. https://doi.org/10.1101/2021.01.16.426973

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