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bioRxiv · 10.1101/2020.12.28.424544

Precision mapping of the mouse brain metabolome

Pang, H.·Li, J.-L.·Hu, X.-L.·Chen, F.·Gao, X.·Zacharias, L. G.·Cai, F.·DeBerardinis, R. J.·Sun, W.·Hu, Z.·Ge, W.-p.
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Abstract

Metabolism is physiologically fundamental to a biological system. Understanding brain metabolism is critical for our comprehensive knowledge of brain function in health and disease. Combining a microarray collection system with targeted metabolomics analysis, here we performed precision mapping of the metabolome in the mouse brain and created maps for 79 metabolites with a resolution of 0.125mm3 per pixel (i.e., brain subregion). The metabolome atlas provides researchers with a useful resource to interpret the vulnerability of specific brain regions to various disease-relevant metabolic perturbations.

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Pang, H., Li, J.-L., Hu, X.-L., Chen, F., Gao, X., Zacharias, L. G., Cai, F., DeBerardinis, R. J., Sun, W., Hu, Z., Ge, W.-p.. 2020-12-29. Precision mapping of the mouse brain metabolome. https://doi.org/10.1101/2020.12.28.424544

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