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bioRxiv · 10.1101/2020.12.21.423843

Effect of Lauric Acid on the Stability of Abeta-Oligomers

Khatua, P.·Jana, A.·Hansmann, U. H. E.
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Abstract

While Alzheimers disease is correlated with the presence of A{beta} fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation we study how presence of fatty acids such as lauric acid changes the stability of pore-forming oligomers built from three-stranded A{beta}42 chains. Such a change would alter the distribution of amyloids in the fatty-acid rich brain environment, and therefore could explain the lower polymorphism observed in A{beta}-fibrils derived from brains of patients with Alzheimers disease. We find that lauric acid stabilizes both ring-like and barrel-shaped models, with the effect being stronger for barrel-like models than for ring-like oligomers.

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Khatua, P., Jana, A., Hansmann, U. H. E.. 2020-12-22. Effect of Lauric Acid on the Stability of Abeta-Oligomers. https://doi.org/10.1101/2020.12.21.423843

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