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bioRxiv · 10.1101/2020.12.10.418855

Identification of eight SARS-CoV-2 ORF7a deletion variants in 2,726 clinical specimens

Rosenthal, S. H.·Kagan, R. M.·Gerasimova, A.·Anderson, B.·grover, D.·Hua, M.·Owen, R.·Lacbawan, F.
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF7a, the ortholog of SARS-CoV ORF7a, is a type I transmembrane protein and plays an important role in virus-host interactions. Deletion variants in ORF7a may influence virulence, but only a few such isolates have been reported. Here, we report 8 unique ORF7a deletion variants of 6 to 96 nucleotides in length identified from 2,726 clinical specimens collected in March of 2020.

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Rosenthal, S. H., Kagan, R. M., Gerasimova, A., Anderson, B., grover, D., Hua, M., Owen, R., Lacbawan, F.. 2020-12-11. Identification of eight SARS-CoV-2 ORF7a deletion variants in 2,726 clinical specimens. https://doi.org/10.1101/2020.12.10.418855

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