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bioRxiv · 10.1101/2020.12.08.416123

The convergence and divergence of episodic and semantic functions across lateral parietal cortex

Abstract

Several decades of neuropsychological and neuroimaging research have highlighted the importance of lateral parietal cortex (LPC) across a myriad of cognitive domains. Yet, despite the prominence of this region the underlying function of LPC remains unclear. Two domains that have placed particular emphasis on LPC involvement are semantic memory and episodic memory retrieval. From each domain, sophisticated models have been proposed as to the underlying function, as well as the more domain-general assumption that LPC is engaged by any form of internally-directed cognition (episodic and semantic retrieval both being examples if this process). Here we directly address these alternatives using a combination of fMRI, functional connectivity and DTI white-matter connectivity data. The results show that ventral LPC (angular gyrus) was positively engaged during episodic retrieval but disengaged during semantic memory retrieval. In addition, the level of activity negatively varied with task difficulty in the semantic task whereas episodic activation was independent of difficulty. In contrast, dorsal LPC (intraparietal sulcus) showed domain general activation that was positively correlated with task difficulty. In terms of functional and structural connectivity, a dorsal-ventral and anterior-posterior gradient of connectivity was found to different processing networks (e.g., mid-angular gyrus (AG) connected with episodic retrieval). We propose a unifying model in which LPC as a whole might share a common underlying neurocomputation (e.g., multimodal buffering) with variations in the emergent, expressed cognitive functions across subregions arising from differences in the underlying white matter connectivity.

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BibTeXRIS

Humphreys, G. F., Jung, J., Lambon Ralph, M.. 2020-12-08. The convergence and divergence of episodic and semantic functions across lateral parietal cortex. https://doi.org/10.1101/2020.12.08.416123

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