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bioRxiv · 10.1101/2020.12.02.408625

Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis

Abstract

The crAss-like phages are ubiquitous and highly abundant members of the human gut virome that infect commensal bacteria of the order Bacteroidales. Although incapable of classical lysogeny, these viruses demonstrate unexplained long-term persistence in the human gut microbiome, dominating the virome in some individuals. Here we demonstrate that rapid phase variation of alternate capsular polysaccharides plays an important role in dynamic equilibrium between phage sensitivity and resistance in B. intestinalis cultures, allowing phage and bacteria to multiply in parallel. The data also suggests the role of concomitant phage persistence mechanisms associated with delayed lysis of infected cells, such as carrier state infection. From an ecological and evolutionary standpoint this type of phage-host interaction is consistent with the Piggyback-the-Winner model, which suggests a preference towards lysogenic or other "benign" forms of phage infection when the host is stably present at high abundance. TeaserCrAss-like phage persistence in Bacteroides is associated with capsule phase-variation and additional unexplored mechanisms.

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Shkoporov, A. N., Khokhlova, E. V., Stephens, N., Hueston, C., Seymour, S., Scholz, D., Ross, R. P., Hill, C.. 2020-12-02. Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis. https://doi.org/10.1101/2020.12.02.408625

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