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bioRxiv · 10.1101/2020.11.06.371880

Adult Neurogenesis in Peripheral Nervous System

Liu, Y.·Gu, X.
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Abstract

Although postnatal neurogenesis has been discovered in some regions of the peripheral nervous system (PNS), only indirect evidences indicated that some progenitors in the adult sciatic nerve and dorsal root ganglion (DRG) serve as a source of newly born sensory neurons. Here, we report the discovery of neurons and neuronal stem cells in the adult rat sciatic nerve. Lineage tracing detected a population of sciatic nerve neurons as progeny of adult neuronal stem cells. With the further finding of labeled DRG neurons in adult transgenic rats with local sciatic nerve staining, we propose a model of adult neurogenesis in the sciatic nerve in which neuronal stem cells in sciatic nerve mature as sensory neurons in adults along the sciatic nerve to DRG. This hypothesis provides a new way to understand sensory formation in adults. Those neuronal stem cells in the sciatic nerve may help to therapy of nerve trauma and disease in the future.

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Liu, Y., Gu, X.. 2020-11-08. Adult Neurogenesis in Peripheral Nervous System. https://doi.org/10.1101/2020.11.06.371880

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