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bioRxiv · 10.1101/2020.10.29.359208

Core Antibiotic-Induced Transcriptional Signatures Reflect Susceptibility to All Members of an Antibiotic Class

Martinsen, M. A.·Jaramillo Cartagena, A.·Bhattacharyya, R. P.
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Abstract

Current growth-based antibiotic susceptibility testing (AST) is too slow to guide early therapy. We previously developed a diagnostic approach that quantifies antibiotic-induced transcriptional signatures to distinguish susceptible from resistant isolates, providing phenotypic AST 24-36h faster than current methods. Here, we show that 10 transcripts optimized for AST of one fluoroquinolone, aminoglycoside, or beta-lactam reflect susceptibility to other members of that class. This finding will streamline development and implementation of this strategy, facilitating efficient antibiotic deployment.

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Martinsen, M. A., Jaramillo Cartagena, A., Bhattacharyya, R. P.. 2020-10-30. Core Antibiotic-Induced Transcriptional Signatures Reflect Susceptibility to All Members of an Antibiotic Class. https://doi.org/10.1101/2020.10.29.359208

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