Bayesian Encoding and Decoding as Distinct Perspectives on Neural Coding

Abstract

One of the most influential, and controversial, ideas in neuroscience has been to understand the brain in terms of Bayesian computations. Unstated differences in how Bayesian ideas are operationalized across different models make it difficult to ascertain both which empirical data support which models, and how Bayesian computations might be implemented by neural circuits. In this paper, we make one such difference explicit by identifying two distinct philosophies that underlie existing neural models of Bayesian inference: one in which the brain recovers experimenter-defined structures in the world from sensory neural activity (Decoding), and another in which the brain represents latent quantities in an internal model that explains its inputs (Encoding). These philosophies require profoundly different assumptions about the nature of inference in the brain, and lead to different interpretations of empirical data. Here, we characterize and contrast both philosophies in terms of motivations, empirical support, and relationship to neural data. We also show that this implicit difference in philosophy underlies some of the debate on whether neural activity is better described as a sampling-based, or a parametric, distributional code. Using a simple model of primary visual cortex as an example, we show mathematically that it is possible that the very same neural activity can be described as probabilistic inference by neural sampling in the Encoding framework while also forming a linear probabilistic population code (PPC) in the Decoding framework. This demonstrates that certain families of Encoding and Decoding models are compatible with each other rather than competing explanations of data. In sum, Bayesian Encoding and Bayesian Decoding are distinct, non-exclusive philosophies, and appreciating their similarities and differences will help organize future work and allow for stronger empirical tests about the nature of inference in the brain.