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bioRxiv · 10.1101/2020.10.08.331678

Antifragile therapy

West, J.·Strobl, M.·Armagost, C.·Miles, R.·Marusyk, A.·Anderson, A. R. A.
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Abstract

Antifragility is a recently coined word used to describe the opposite of fragility. Systems or organisms can be described as antifragile if they derive a benefit from systemic variability, volatility, randomness, or disorder. Herein, we introduce a mathematical framework to quantify the fragility or antifragility of cancer cell lines in response to treatment variability. This framework enables straightforward prediction of the optimal dose treatment schedule for a range of treatment schedules with identical cumulative dose. We apply this framework to non-small-cell lung cancer cell lines with evolved resistance to ten anti-cancer drugs. We show the utility of this antifragile framework when applied to 1) treatment resistance, and 2) collateral sensitivity of sequential monotherapies.

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West, J., Strobl, M., Armagost, C., Miles, R., Marusyk, A., Anderson, A. R. A.. 2020-10-09. Antifragile therapy. https://doi.org/10.1101/2020.10.08.331678

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