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bioRxiv · 10.1101/2020.09.26.315069

Maternal high fiber diet protects offspring on diabetogenic diet in the Nile rat

Toh, H.·Thomson, J.·Jiang, P.
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Abstract

Previous studies have reported that maternal malnutrition is linked to increased risk of developing type 2 diabetes in adulthood. Although several diabetic risk factors associated with early life environment have been identified, protective factors remain elusive. Here, we modulate the early life environment using a maternal high fiber diet to investigate whether the offspring are protected from type 2 diabetes. We examined the interplay between early life environment (maternal diet) and later life environment (offspring diet) using a longitudinal study with 671 Nile rats. We found that exposure to a high fiber maternal diet prior to weaning significantly lowers the risk of diet-induced diabetes in the offspring. Interestingly, offspring consuming a high fiber diet after weaning do not get diet-induced diabetes, even when exposed to a diabetogenic maternal diet. Here, we provide the first evidence that the protective effect of high fiber can be transmitted to the offspring through a maternal diet, which has important implications in diabetes prevention.

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Toh, H., Thomson, J., Jiang, P.. 2020-09-28. Maternal high fiber diet protects offspring on diabetogenic diet in the Nile rat. https://doi.org/10.1101/2020.09.26.315069

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