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bioRxiv · 10.1101/2020.09.01.278440

Breathing new life into the critical oxygen partial pressure (Pcrit): a new definition, interpretation and method of determination

Abstract

The critical oxygen partial pressure (Pcrit) is most commonly defined as the oxygen partial pressure below which an animals standard metabolic rate can no longer be maintained. It is widely interpreted as measure of hypoxia tolerance, which influences a species aerobic scope and, thus, constrains biogeography. However, both the physiology underlying that interpretation and the methodology used to determine Pcrit remain topics of active debate. The debate remains unresolved in part because Pcrit, as defined above, is a purely descriptive metric that lacks a clear mechanistic basis. Here we redefine Pcrit as the PO2 at which physiological oxygen supply is maximized and refer to these values, thus determined, as Pcrit-. The oxygen supply capacity () is a species- and temperature-specific coefficient that describes the slope of the relationship between the maximum achievable metabolic rate and PO2. This is easily determined using respirometry and provides a precise and robust estimate of the minimum oxygen pressure required to sustain any metabolic rate. To determine , it is not necessary for an individual animal to maintain a consistent metabolic rate throughout a trial (i.e. regulation) nor for the metabolic rate to show a clear break-point at low PO2. We show that Pcrit- can be determined at any metabolic rate as long as the organisms oxygen supply machinery reaches its maximum capacity at some point during the trial. We reanalyze published representative Pcrit trials for 40 species across five phyla, as well as complete datasets from six additional species, five of which have not previously been published. Values determined using the Pcrit- method are strongly correlated with Pcrit values reported in the literature. Advantages of Pcrit- include: 1) Pcrit- is directly measured without the need for complex statistics that hinder measurement and interpretation; 2) it makes clear that Pcrit is a measure of oxygen supply, which does not necessarily reflect hypoxia tolerance; 3) it alleviates many of the methodological constraints inherent in existing methods; 4) it provides a means of predicting the maximum metabolic rate achievable at any PO2, 5) Pcrit- sheds light on the temperature- and size-dependence of oxygen supply and metabolic rate and 6) Pcrit- can be determined with greater precision than traditional Pcrit.

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Seibel, B. A., Andres, A., Birk, M. A., Burns, A., Shaw, C. T., Timpe, A., Welsh, C.. 2020-09-02. Breathing new life into the critical oxygen partial pressure (Pcrit): a new definition, interpretation and method of determination. https://doi.org/10.1101/2020.09.01.278440

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