Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

Wheater, E. N.; Shenkin, S. D.; Munoz Maniega, S.; Valdes Hernandez, M.; Wardlaw, J.; Deary, I.; Bastin, M. E.; Boardman, J. P.; Cox, S. R.

doi:10.1101/2020.08.27.270033

bioRxiv · 10.1101/2020.08.27.270033

Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

Wheater, E. N.·Shenkin, S. D.·Munoz Maniega, S.·Valdes Hernandez, M.·Wardlaw, J.·Deary, I.·Bastin, M. E.·Boardman, J. P.·Cox, S. R.

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Abstract

Birth weight, an indicator of fetal growth, is associated with cognitive outcomes in early life and risk of metabolic and cardiovascular disease across the life course. Cognitive ability in early life is predictive of cognitive ability in later life. Brain health in older age, defined by MRI features, is associated with cognitive performance. However, little is known about how variation in normal birth weight impacts on brain structure in later life. In a community dwelling cohort of participants in their early seventies we tested the hypothesis that birthweight is associated with the following MRI features: total brain (TB), grey matter (GM) and normal appearing white matter (NAWM) volumes; whiter matter hyperintensity (WMH) volume; a general factor of fractional anisotropy (gFA) and peak width skeletonised mean diffusivity (PSMD) across the white matter skeleton. We also investigated the associations of birthweight with cortical surface area, volume and thickness. Birthweight was positively associated with TB, GM and NAWM volumes in later life ({beta} [≥] 0.194), and with regional cortical surface area but not gFA, PSMD, WMH volume, or cortical volume or thickness. These positive relationships appear to be explained by larger intracranial volume rather than by age-related tissue atrophy, and are independent of body height and weight in adulthood. This suggests that larger birthweight is linked to increased brain tissue reserve in older life, rather than a resilience to age-related changes in brain structure, such as tissue atrophy or WMH volume. Significance StatementCognitive brain ageing carries a high personal, societal and financial cost and understanding its developmental origins is important for identifying possible preventative strategies. In a sample of older participants from the Lothian Birth Cohort 1936 we were able to explore the neurobiological correlates of birth weight, which is indicative of the fetal experience. We find that higher birth weight is related to larger brain tissue volumes in later life, but does not modify the trajectory of age-related change. This suggests that early life growth confers preserved differentiation, rather than differential preservation with regards to brain reserve. That these effects are detectable into later life indicates that this variable may be valuable biomarker in the epidemiology of ageing.

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Wheater, E. N., Shenkin, S. D., Munoz Maniega, S., Valdes Hernandez, M., Wardlaw, J., Deary, I., Bastin, M. E., Boardman, J. P., Cox, S. R.. 2020-08-28. Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure. https://doi.org/10.1101/2020.08.27.270033

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