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bioRxiv · 10.1101/2020.08.24.264499

The nucleoid-associated protein IHF acts as a domainin protein coordinating the bacterial virulence traits with global transcription

Abstract

Bacterial pathogenic growth requires a swift coordination of pathogenicity functions with various kinds of environmental stresses encountered in the course of host infection. Among the factors critical for bacterial adaptation are changes of DNA topology and binding effects of nucleoid-associated proteins transducing the environmental signals to the chromosome and coordinating the global transcriptional response to stress. In this study we use the model phytopathogen Dickeya dadantii to analyse the organisation of transcription by the nucleoid-associated protein IHF. We determine both phenotypic effects of ihfA mutation on D. dadantii virulence and the transcriptional response under various conditions of growth. For the first time in enterobacteria, we examine the transcriptome of an IHF-depleted mutant under conditions of DNA relaxation, revealing a subtle interplay between IHF and DNA topology. We show that this mutation reorganises the genomic expression by altering the distribution of DNA supercoils along the chromosome at different length scales, thus affecting many virulence genes involved in both symptomatic and asymptomatic phases of infection, including those required for pectin catabolism. Altogether, we propose that IHF is a "domainin" protein, the inactivation of which impairs the coordination of chromosomal stress-response domains harbouring various virulence traits, thus abrogating the pathogenicity of D. dadantii.

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BibTeXRIS

Reverchon, S., Meyer, S., Forquet, R., Hommais, F., Muskhelishvili, G., Nasser, w.. 2020-08-25. The nucleoid-associated protein IHF acts as a domainin protein coordinating the bacterial virulence traits with global transcription. https://doi.org/10.1101/2020.08.24.264499

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