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bioRxiv · 10.1101/2020.08.20.260224

H-MAGMA, inheriting a shaky statistical foundation, yields excess false positives

Yurko, R. J.·Roeder, K.·Devlin, B.·G'Sell, M.
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Abstract

The snp-wise mean model of Multi-marker Analysis of GenoMic Annotation is often used to perform gene-level testing for association with disease and other phenotypes. This methodology, in turn, forms the foundation for H-MAGMA. Unfortunately, that foundation is unsound, with implications for H-MAGMA results published in Nature Neuroscience regarding genes associated with psychiatric disorders: e.g., only 125 of H-MAGMAs 275 reported discoveries for autism replicate when the foundations flaws are corrected.

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Yurko, R. J., Roeder, K., Devlin, B., G'Sell, M.. 2020-08-22. H-MAGMA, inheriting a shaky statistical foundation, yields excess false positives. https://doi.org/10.1101/2020.08.20.260224

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