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bioRxiv · 10.1101/2020.08.19.257204

Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan

Okemoto-Nakamura, Y.·Someya, K.·Yamaji, T.·Saito, K.·Takeda, M.·Hanada, K.
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Abstract

Polio or poliomyelitis is a disabling and life-threatening disease caused by poliovirus (PV). As a consequence of global polio vaccination efforts, wild PV serotype 2 has been eradicated, and wild PV serotypes 1- and 3-transmitted cases have been largely eliminated except for in limited regions around the world. However, vaccine-derived PV, pathogenically reverted live PV vaccine strains in vaccinated humans, has become a serious issue. For the global eradication of polio, the World Health Organization is conducting the third edition of the Global Action Plan, which is requesting stringent control of potentially PV-infected materials. To facilitate the mission, we generated a PV-nonsusceptible Vero cell subline, which may serve as an ideal replacement of standard Vero cells to isolate emerging/re-emerging viruses without the risk of generating PV-infected materials.

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Okemoto-Nakamura, Y., Someya, K., Yamaji, T., Saito, K., Takeda, M., Hanada, K.. 2020-08-19. Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan. https://doi.org/10.1101/2020.08.19.257204

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