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bioRxiv · 10.1101/2020.08.17.253955

PIE-1 promotes SUMOylation and activation of HDAC1 during the C. elegans oogenesis

Abstract

Germlines shape and balance heredity, integrating and regulating information from both parental and foreign sources. Insights into how the germline handles information have come from the identification of factors that specify or maintain the germline fate. In early C. elegans embryos, the CCCH zinc-finger protein PIE-1 localizes to the germline where it prevents somatic differentiation programs. Here we show that PIE-1 also functions in the meiotic ovary where it becomes SUMOylated and engages the SUMO-conjugating machinery. Using whole-proteome mass spectrometry to detect SUMO-conjugated proteins, we identify HDAC SUMOylation as a target of PIE-1. Our findings suggest that SUMOylation activates HDAC, lowering histone acetylation and enhancing Argonaute-mediated surveillance in the germline.

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Kim, H., Ding, Y.-H., Lu, S., Zuo, M.-Q., Conte, D., Dong, M.-Q., Mello, C.. 2020-08-17. PIE-1 promotes SUMOylation and activation of HDAC1 during the C. elegans oogenesis. https://doi.org/10.1101/2020.08.17.253955

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