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bioRxiv · 10.1101/2020.08.03.235044

Striatal low-threshold spiking interneurons locally gate dopamine during learning

Holly, E. N.·Davatolhagh, M. F.·Espana, R. A.·Fuccillo, M. V.
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Abstract

Low-threshold spiking interneurons (LTSIs) in the dorsomedial striatum are potent modulators of goal-directed learning. Here, we uncover a novel function for LTSIs in locally and directly gating striatal dopamine, using in vitro fast scan cyclic voltammetry as well as in vivo GRAB-DA sensor imaging and pharmacology during operant learning. We demonstrate that LTSIs, acting via GABAB signaling, attenuate dopamine release, thereby serving as local coordinators of striatal plasticity.

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Holly, E. N., Davatolhagh, M. F., Espana, R. A., Fuccillo, M. V.. 2020-08-03. Striatal low-threshold spiking interneurons locally gate dopamine during learning. https://doi.org/10.1101/2020.08.03.235044

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