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bioRxiv · 10.1101/2020.07.29.226894

Tolerance of liver fluke infection varies between breeds and producers in Scottish beef cattle

Abstract

Liver fluke (Fasciola spp.) are important helminth parasites of livestock globally and cause significant reductions in health and productivity of beef cattle. Attempts to control fluke have been thwarted by the difficulty of vaccine design, the evolution of flukicide resistance, and the need to control the intermediate snail host. Mechanisms to reduce the impact of parasites on animal performance have typically focused on promoting host resistance - defined as the ability of the host to kill and remove the parasite from its system - and such strategies include improving protein nutrition or selectively breeding for resistance. Organisms, however, have another broad mechanism for mitigating the impact of parasites: they can show tolerance, defined as the ability to maintain health or performance under increasing parasite burden. Tolerance has been studied in the plant literature for over a century, but there are very few empirical studies of parasite tolerance in livestock. In this study, we used data collected from >90,000 beef cattle to estimate the impact of the severity of liver fluke infection on performance and variation in tolerance of fluke. Severity of liver fluke infection was estimated using liver "fibrosis score" on a scale of 0-3 and performance estimated as (1) age at slaughter and (2) daily dead weight gain. Animals with higher fibrosis scores were slaughtered around two weeks later than animals with no fluke, and gained around 10g less weight per day. There was also considerable variation in these effects of fibrosis score, such that animals from different producers and breeds varied in their tolerance of fluke infection. While breeds did not vary in the association between fibrosis and age at slaughter, there was considerable variation among producers: high fibrosis score delayed slaughter by up to 50 days in some producers, but not at all in others. Meanwhile, there was support for variation in the slope of daily dead weight gain on fibrosis score among both breeds and producers, with some unaffected by high fluke scores and some breeds and producers experiencing a 20g/day lower weight gain under high fluke scores. Our results point to the potential for both environmental and genetic variation in tolerance of liver fluke in cattle, paving the way for quantitative genetic and nutritional research into the feasibility of promoting tolerance as a disease mitigation strategy. ImplicationsPromoting tolerance of disease could help mitigate the impact of disease on livestock productivity, but little research has explored variation in tolerance of livestock diseases or the possibility of promoting tolerance as a mitigation strategy. We used abattoir data to demonstrate that beef cattle vary in their tolerance of fluke infection: while animals from some breeds and some producers experience no impact of fluke on production, others show a large negative effect. Thus, promoting tolerance through management and/or selective breeding could offer a means of reducing the impact of liver fluke on cattle performance.

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BibTeXRIS

Hayward, A., Skuce, P. J., McNeilly, T. N.. 2020-07-29. Tolerance of liver fluke infection varies between breeds and producers in Scottish beef cattle. https://doi.org/10.1101/2020.07.29.226894

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