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bioRxiv · 10.1101/2020.07.26.221523

Regulated distribution of mitochondria in touch receptor neurons of C. elegans influences touch response

Awasthi, A.·Modi, S.·Hegde, S.·Chatterjee, A.·Mondal, S.·Romero, E.·Sure, G. R.·Koushika, S. P.
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Abstract

Density of mitochondria and their localization at specific sub-cellular regions of the neurons is regulated by molecular motors, their adaptors and the cytoskeleton. However, the regulation of the mitochondrial density, the positioning of mitochondria along the neuronal process and the role of axonal mitochondria in neuronal function remain poorly understood. This study shows that the density of mitochondria in C. elegans touch receptor neuron processes remains constant through development. Simulations show that mitochondrial positioning along parts of the neuronal process that are devoid of synapses is regulated. Additionally, we also demonstrate that axonal mitochondria are necessary for maintaining touch responsiveness.

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Awasthi, A., Modi, S., Hegde, S., Chatterjee, A., Mondal, S., Romero, E., Sure, G. R., Koushika, S. P.. 2020-07-26. Regulated distribution of mitochondria in touch receptor neurons of C. elegans influences touch response. https://doi.org/10.1101/2020.07.26.221523

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