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bioRxiv · 10.1101/2020.07.04.158063

Somatic variant analysis of linked-reads sequencing data with Lancet

Musunuri, R.·Arora, K.·Corvelo, A.·Shah, M.·Shelton, J.·Zody, M. C.·Narzisi, G.
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Abstract

Summary We present a new version of the popular somatic variant caller, Lancet, that supports the analysis of linked-reads sequencing data. By seamlessly integrating barcodes and haplotype read assignments within the colored De Bruijn graph local-assembly framework, Lancet computes a barcode-aware coverage and identifies variants that disagree with the local haplotype structure.Availability and Implementation Lancet is implemented in C++ and is available for academic and non-commercial research purposes as an open-source package at https://github.com/nygenome/lancet.Contact gnarzisi{at}nygenome.orgCompeting Interest StatementThe authors have declared no competing interest.View Full Text

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Musunuri, R., Arora, K., Corvelo, A., Shah, M., Shelton, J., Zody, M. C., Narzisi, G.. 2020-07-06. Somatic variant analysis of linked-reads sequencing data with Lancet. https://doi.org/10.1101/2020.07.04.158063

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