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bioRxiv · 10.1101/2020.07.02.184218

Urine metabolomics of rats with chronic atrophic gastritis

zu, g.·Zu, G.-X.·Sun, Q.-Q.·chen, j.·Liu, X.-J.·Sun, K.-Y.·Zhang, L.-K.·li, l.·Huang, H.-l.·Han, T.
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Abstract

Background/Aim: To use liquid chromatography-mass spectrometry (LC-MS) to identify endogenous differential metabolites in the urine of rats with chronic atrophic gastritis (CAG). Materials and Methods: Methylnitronitrosoguanidine (MNNG) was used to produce a CAG model in Wistar rats, and HE staining was used to determine the pathological model. LC-MS was used to detect the differential metabolic profiles in rat urine. Diversified analysis was performed by the statistical method. Results: Compared with the control group, the model group had 68 differential metabolites, 25 that were upregulated and 43 that were downregulated. The main metabolic pathways were D-glutamine and D-glutamic acid metabolism, histidine metabolism and purine metabolism. Conclusion: By searching for differential metabolites and metabolic pathways in the urine of CAG rats, this study provides effective experimental data for the pathogenesis and clinical diagnosis of CAG.View Full Text

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zu, g., Zu, G.-X., Sun, Q.-Q., chen, j., Liu, X.-J., Sun, K.-Y., Zhang, L.-K., li, l., Huang, H.-l., Han, T.. 2020-07-02. Urine metabolomics of rats with chronic atrophic gastritis. https://doi.org/10.1101/2020.07.02.184218

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