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bioRxiv · 10.1101/2020.06.23.168393

Anti-inflammatory Activity of Lefamulin in a Lipopolysaccharide-Induced Lung Neutrophilia Model

Hafner, M.·Paukner, S.·Wicha, W. W.·Hrvacic, B.·Gelone, S. P.
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Abstract

Lefamulin is a novel pleuromutilin antibiotic approved for the treatment of community-acquired bacterial pneumonia. This study demonstrated anti-inflammatory activity of lefamulin in a murine lipopolysaccharide-induced lung neutrophilia model. Pretreatment of mice at clinically relevant lefamulin subcutaneous doses (35, 70, 140 mg/kg [free base]) followed by intranasal lipopolysaccharide challenge (5 g/50 L/mouse) demonstrated significant, dose-dependent reductions in total and neutrophil cell counts in bronchoalveolar lavage fluid samples, with reductions comparable to oral dexamethasone (0.5 mg/kg) pretreatment.

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Hafner, M., Paukner, S., Wicha, W. W., Hrvacic, B., Gelone, S. P.. 2020-06-26. Anti-inflammatory Activity of Lefamulin in a Lipopolysaccharide-Induced Lung Neutrophilia Model. https://doi.org/10.1101/2020.06.23.168393

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