Towards a new treatment against polymicrobial infections: high antibacterial activity of lemon IntegroPectin against Pseudomonas aeruginosa and Escherichia coli

Presentato, A.; Scurria, A.; Albanese, L.; Picone, P.; Pagliaro, M.; Zabini, F.; Meneguzzo, F.; Alduina, R.; Nuzzo, D.; Ciriminna, R.

doi:10.1101/2020.06.16.154229

bioRxiv · 10.1101/2020.06.16.154229

Towards a new treatment against polymicrobial infections: high antibacterial activity of lemon IntegroPectin against Pseudomonas aeruginosa and Escherichia coli

Presentato, A.·Scurria, A.·Albanese, L.·Picone, P.·Pagliaro, M.·Zabini, F.·Meneguzzo, F.·Alduina, R.·Nuzzo, D.·Ciriminna, R.

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Abstract

Lemon IntegroPectin obtained via hydrodynamic cavitation of waste lemon peel in water only shows high antibacterial activity against two Gram-negative bacteria, Pseudomonas aeruginosa and Escherichia coli. The antibacterial effect against the ubiquitous pathogen P. aeruginosa was evaluated in terms of the minimal bactericidal (MBC) and minimal inhibitory concentration (MIC). Preliminary insight on the antibacterial mechanism of IntegroPectin originates from investigating its inhibitory activity against E. coli. Given the non-cytotoxic nature of citrus IntegroPectin and the ease of its reproducible production in large amounts, the route is open to the industrial development of a new antimicrobial treatment against polymicrobial infections unlikely to develop drug resistance.

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Presentato, A., Scurria, A., Albanese, L., Picone, P., Pagliaro, M., Zabini, F., Meneguzzo, F., Alduina, R., Nuzzo, D., Ciriminna, R.. 2020-06-17. Towards a new treatment against polymicrobial infections: high antibacterial activity of lemon IntegroPectin against Pseudomonas aeruginosa and Escherichia coli. https://doi.org/10.1101/2020.06.16.154229

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