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bioRxiv · 10.1101/2020.06.15.153387

The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection

Beddingfield, B.·Iwanaga, N.·Zheng, W.·Roy, C. J.·Hu, T. Y.·Kolls, J.·Bix, G.
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Abstract

Many efforts to design and screen therapeutics for severe acute respiratory syndrome coronavirus (SARS-CoV-2) have focused on inhibiting viral cell entry by disrupting ACE2 binding with the SARS-CoV-2 spike protein. This work focuses on inhibiting SARS-CoV-2 entry through a hypothesized 5{beta}1 integrin-based mechanism, and indicates that inhibiting the spike protein interaction with 5{beta}1 integrin (+/- ACE2), and the interaction between 5{beta}1 integrin and ACE2 using a molecule ATN-161 represents a promising approach to treat COVID-19.

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Beddingfield, B., Iwanaga, N., Zheng, W., Roy, C. J., Hu, T. Y., Kolls, J., Bix, G.. 2020-06-16. The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection. https://doi.org/10.1101/2020.06.15.153387

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