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bioRxiv · 10.1101/2020.06.12.148510

Bacteriome diversity of blackflies gut and association with Onchocerca volvulus, the causative agent of onchocerciasis in Mbam valley (Center Region, Cameroon)

Abstract

BackgroundVector control using larvicides is the main alternative strategy to address limits of preventive chemotherapy using ivermectin to fight onchocerciasis. However, it remains substantially limited by implementation difficulties, ecological concerns and resistance of vector populations. Therefore, efficient and environmentally safe alternative control strategies are still needed. This study explores the role of blackfly bacterial communities both on vector competence and refractoriness to O. volvulus infection in order to determine their potential as a novel vector control-based approach to fight onchocerciasis. Principal findingsA total of 1,270 blackflies were dissected and the infection rate was 10.1%, indicative of ongoing transmission of onchocerciasis in the surveyed communities. Sequencing process revealed 19 phyla and 210 genera, highlighting the diversity of gut blackflies bacterial communities. Wolbachia was the predominant genus with 70% of relative abundance of blackflies gut bacterial communities. Serratia sp and Acidomonas genera were significantly abundant among infected blackflies (p=0.043 and p=0.027, respectively), whereas other genera as Brevibacterium were associated with the absence of infection (p=0.008). Conclusion/SignificanceThis study revealed that blackfly native bacteria are potentially involved in infection by O. volvulus, either by facilitating or preventing the parasite infestation of the vector. These bacteria represent an interesting potential as a biological target for a novel approach of vector control to fight onchocerciasis. Author summaryStudies of arthropods involved in vector-borne diseases (tsetse flies, mosquitoes, and drosophila) demonstrated the importance of their native bacteria either to ease infection and transmission of human pathogenic microorganisms including parasites or on the contrary to induce host protective effects against these parasites. Indeed, some native bacteria of arthropod vectors are now recognized to be associated either with the resistance of their hosts to parasitic infections, or the reduction of their hosts viability in case of the parasite infestation, thus highlighting the potential of such bacteria to be used as biological tool for vector control strategies. However, such bacteria have never been described on blackfly, an arthropod transmitting Onchocerca volvulus, which is the parasite responsible of onchocerciasis commonly known as river blindness. This study aimed to fill this gap by investigating the bacterial diversity of blackfly bacteriome and describing the possible role of bacteria communities in susceptibility/resistance features of the blackflies to O. volvulus infection, and therefore their potential as biological targets or tool for vector control. The screening of these blackflies native bacteria during this study, highlighted some bacteria genera of interest with significant association either with the absence of O. volvulus in blackfly or with vector infection.

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BibTeXRIS

Efon Ekangouo, A., Nana Djeunga, H., Sempere, G., Kamgno, J., Njiokou, F., Moundipa Fewou, P., Geiger, A.. 2020-06-12. Bacteriome diversity of blackflies gut and association with Onchocerca volvulus, the causative agent of onchocerciasis in Mbam valley (Center Region, Cameroon). https://doi.org/10.1101/2020.06.12.148510

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