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bioRxiv · 10.1101/2020.06.10.144014

The influence of Schizotypy on Event-Related Oscillations in Sensory Gating during early Infant Development.

Smith, E. S.·Crawford, T. J.·Reid, V. M.
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Abstract

Maternal schizotypic personality is thought to influence childhood risk for mental health and is a personality dimension elevated among schizophrenia-spectrum patients and their first-degree relatives, in whom neuro-oscillatory deficits have been observed. The current study investigated whether 6-month-old infants (n =46), and a subset of their biological mothers (n =34), who identified as either schizotypic (n =14) non-schizotypic (n =14), or an intermediate group (n =6), displayed reduced evoked-oscillatory activity. All mothers completed the Oxford-Liverpool Inventory of Feelings and Experiences as an index of schizotypy dimensionality. An auditory paired-tone paradigm was used to probe oscillatory activity, revealing that although the infants evoked-oscillations displayed differences between Stimulus 1 and 2, there were no group differences between infants of schizotypic and control mothers. Their mothers, however, displayed differences, with reduced amplitudes toward Stimulus 1 in schizotypic mothers; consistent with literature on early sensory processes, showing sensory gating is impaired in schizophrenia-spectrum disorders.

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Smith, E. S., Crawford, T. J., Reid, V. M.. 2020-06-10. The influence of Schizotypy on Event-Related Oscillations in Sensory Gating during early Infant Development.. https://doi.org/10.1101/2020.06.10.144014

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