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bioRxiv · 10.1101/2020.05.28.122234

The Caribbean-Hispanic Alzheimer's Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms

Felsky, D.·Sariya, S.·Santa-Maria, I.·Schneider, J. A.·Bennett, D. A.·Mayeux, R. P.·De Jager, P. L.·Tosto, G.
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Abstract

Ethnicity impacts Alzheimers disease risk, especially among Caribbean-Hispanics. We report the first RNA-sequencing analysis of brain tissue from 45 Alzheimers disease and control Caribbean-Hispanics. Data were compared with two independent samples of non-Hispanic Caucasians (total n=729). By identifying and characterizing those genes with ancestry- and region-specific expression patterns in Alzheimers disease, we reveal molecular insights that may help explain epidemiological disparities in this understudied aging population.

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Felsky, D., Sariya, S., Santa-Maria, I., Schneider, J. A., Bennett, D. A., Mayeux, R. P., De Jager, P. L., Tosto, G.. 2020-05-31. The Caribbean-Hispanic Alzheimer's Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms. https://doi.org/10.1101/2020.05.28.122234

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