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bioRxiv · 10.1101/2020.05.20.105809

Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPS

Roman-Hurtado, F.·Sanchez-Hidalgo, M.·Martin-Serrano, J. M.·Ortiz-Lopez, F. J.·Genilloud, O.
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Abstract

1.Cacaoidin is the first member of the new lanthidin RiPP family, a lanthipeptide produced by the strain Streptomyces cacaoi CA-170360 with unprecedented features such as an unusually high number of D-amino acids, a double methylation in the N-terminal alanine and a tyrosine residue glycosylated with a disaccharide. In this work, we describe the complete identification, cloning and heterologous expression of the cacaoidin biosynthetic gene cluster, which shows unique RiPP genes.

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Roman-Hurtado, F., Sanchez-Hidalgo, M., Martin-Serrano, J. M., Ortiz-Lopez, F. J., Genilloud, O.. 2020-05-22. Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPS. https://doi.org/10.1101/2020.05.20.105809

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