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bioRxiv · 10.1101/2020.05.18.101618

Whole-Brain High-Resolution Metabolite Mapping with 3D Compressed-Sensing-SENSE-LowRank 1H FID-MRSI

Klauser, A.·Klauser, P.·Grouiller, F.·Courvoisier, S.·Lazeyras, F.
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Abstract

There is a growing interest in the neuroscience community to map the distribution of brain metabolites in vivo. Magnetic resonance spectroscopic imaging (MRSI) is often limited by either a poor spatial resolution and/or a long acquisition time which severely limits its applications for clinical or research purposes. Building on a recently developed technique of acquisition-reconstruction for 2D MRSI, we combined fast Cartesian 1H-FID-MRSI acquisition sequence, compressed-sensing acceleration, and low-rank total-generalized-variation constrained reconstruction to produce 3D high-resolution whole-brain MRSI with a significant acquisition time reduction. We first evaluated the acceleration performance using retrospective undersampling of a fully-sampled dataset. Second, a 20 min accelerated MRSI acquisition was performed on the brain of three healthy volunteers resulting in metabolite maps with 5 mm isotropic resolution. The metabolite maps exhibited the detailed neurochemical composition of all brain regions and revealed parts of the underlying brain anatomy. The latter assessment used previous reported knowledge and a brain atlas-based analysis to show consistency of the concentration contrasts and ratio across all brain regions. These results acquired on a clinical 3 Tesla MRI successful combinae of the 3D 1H-FID-MRSI with a constrained reconstruction to produce detailed mapping of metabolite concentrations at high-resolution over the whole brain, with an acquisition time suitable for clinical or research settings.

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Klauser, A., Klauser, P., Grouiller, F., Courvoisier, S., Lazeyras, F.. 2020-05-20. Whole-Brain High-Resolution Metabolite Mapping with 3D Compressed-Sensing-SENSE-LowRank 1H FID-MRSI. https://doi.org/10.1101/2020.05.18.101618

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