Mapping Cognitive Brain Functions at Scale

Balasubramani, P. P.; Ojeda, A.; Maric, V.; Le, H.; Grennan, G.; Alim, F.; Zafar-Khan, M.; Diaz-Delgado, J.; Silveira, S.; Ramanathan, D.; Mishra, J.

doi:10.1101/2020.05.14.097014

bioRxiv · 10.1101/2020.05.14.097014

Mapping Cognitive Brain Functions at Scale

Balasubramani, P. P.·Ojeda, A.·Maric, V.·Le, H.·Grennan, G.·Alim, F.·Zafar-Khan, M.·Diaz-Delgado, J.·Silveira, S.·Ramanathan, D.·Mishra, J.

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Abstract

A fundamental set of cognitive abilities enable humans to efficiently process goal-relevant information, suppress irrelevant distractions, maintain information in working memory, and act flexibly in different behavioral contexts. Yet, studies of human cognition and their underlying neural mechanisms usually evaluate these cognitive constructs in silos, instead of comprehensively in-tandem within the same individual. Here, we developed a scalable, mobile platform, "BrainE" (short for Brain Engagement), to rapidly assay several essential aspects of cognition simultaneous with wireless electroencephalography (EEG) recordings. Using BrainE, we rapidly assessed five aspects of cognition including (1) selective attention, (2) response inhibition, (3) working memory, (4) flanker interference and (5) emotion interference processing, in 102 healthy young adults. We evaluated stimulus encoding in all tasks using the EEG neural recordings, and isolated the cortical sources of the spectrotemporal EEG dynamics. Additionally, we used BrainE in a two-visit study in 24 young adults to investigate the reliability of the neuro-cognitive data as well as its plasticity to transcranial magnetic stimulation (TMS). We found that stimulus encoding on multiple cognitive tasks could be rapidly assessed, identifying common as well as distinct task processes in both sensory and cognitive control brain regions. Event related synchronization (ERS) in the theta (3-7 Hz) and alpha (8-12 Hz) frequencies as well as event related desynchronization (ERD) in the beta frequencies (13-30 Hz) were distinctly observed in each task. The observed ERS/ERD effects were overall anticorrelated. The two-visit study confirmed high test-retest reliability for both cognitive and neural data, and neural responses showed specific TMS protocol driven modulation. We also show that the global cognitive neural responses are sensitive to mental health symptom self-reports. This first study with the BrainE platform showcases its utility in studying neuro-cognitive dynamics in a rapid and scalable fashion. HighlightsO_LIRapid and scalable EEG recordings reveal common and distinct cortical activations across five core cognitive tasks. C_LIO_LIData acquired across visits one-week-apart show high test-retest reliability for both cognitive and neural measurements. C_LIO_LIEvoked neural responses during emotion interference processing demonstrate specific short-term plasticity driven by type of neurostimulation. C_LIO_LICognitively evoked neural responses are sensitive to variations in mental health symptoms. C_LI

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Balasubramani, P. P., Ojeda, A., Maric, V., Le, H., Grennan, G., Alim, F., Zafar-Khan, M., Diaz-Delgado, J., Silveira, S., Ramanathan, D., Mishra, J.. 2020-05-16. Mapping Cognitive Brain Functions at Scale. https://doi.org/10.1101/2020.05.14.097014

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