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bioRxiv · 10.1101/2020.05.12.089128

Determination and correction of aberrations in full field OCT using phase gradient autofocus by maximizing the likelihood function

Matkivsky, V.·Moiseev, A.·Shilyagin, P.·Rodionov, A.·Spahr, H.·Pfaffle, C.·Huttmann, G.·Hillmann, D.·Gelikonov, G.
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Abstract

A method for numerical estimation and correction of aberrations of the eye in fundus imaging with optical coherence tomography (OCT) is presented. Aberrations are determined statistically by using the estimate based on likelihood function maximization. The method can be considered as an extension of the phase gradient autofocusing algorithm in synthetic aperture radar imaging to 2D optical aberrations correction. The efficiency of the proposed method has been demonstrated in OCT fundus imaging with 6{lambda} aberrations. After correction, single photoreceptors were resolved. It is also shown that wavefront distortions with high spatial frequencies can be determined and corrected. O_FIG_DISPLAY_L [Figure 1] M_FIG_DISPLAY C_FIG_DISPLAY Graphical Abstract for Table of Contents[Text. This work is dedicated to development a method for numerical estimation and correction of aberrations of the eye in fundus imaging with OCT. Aberration evaluation is performed statistically by using estimate based on likelihood function maximization. The efficiency of the proposed method has been demonstrated in OCT fundus imaging with 6{lambda} aberrations. It has been shown that spatial high-frequency wavefront distortions can be determined] O_FIG_DISPLAY_R [Figure 2] M_FIG_DISPLAY C_FIG_DISPLAY

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Matkivsky, V., Moiseev, A., Shilyagin, P., Rodionov, A., Spahr, H., Pfaffle, C., Huttmann, G., Hillmann, D., Gelikonov, G.. 2020-05-14. Determination and correction of aberrations in full field OCT using phase gradient autofocus by maximizing the likelihood function. https://doi.org/10.1101/2020.05.12.089128

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