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bioRxiv · 10.1101/2020.05.11.088062

COTAN: Co-expression Table Analysis for scRNA-seq data

Galfre', S. G.·Morandin, F.·Pietrosanto, M.·Cremisi, F.·Helmer-Citterich, M.
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Abstract

Estimating co-expression of cell identity factors in single-cell transcriptomes is crucial to decode new mechanisms of cell state transition. Due to the intrinsic low efficiency of single-cell mRNA profiling, novel computational approaches are required to accurately infer gene co-expression in a cell population. We introduce COTAN, a statistical and computational method to analyze the co-expression of gene pairs at single cell level, providing the foundation for single-cell gene interactome analysis.

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Galfre', S. G., Morandin, F., Pietrosanto, M., Cremisi, F., Helmer-Citterich, M.. 2020-05-12. COTAN: Co-expression Table Analysis for scRNA-seq data. https://doi.org/10.1101/2020.05.11.088062

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