Sensorimotor hallucinationsin Parkinson's disease

Bernasconi, F.; Blondiaux, E.; Potheegadoo, J.; Stripeikyte, G.; Pagonabarraga, J.; Bejr-Kasem, H.; Bassolino, M.; Akselrod, M.; Martinez-Horta, S.; Sampedro, F.; Hara, M.; Horvath, J.; Franza, M.; Konik, S.; Bereau, M.; Ghika, J.-A.; Burkhard, P. R.; Van De Ville, D.; Faivre, N.; Rognini, G.; Krack, P.; Kulisevsky, J.; Blanke, O.

doi:10.1101/2020.05.11.054619

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bioRxiv · 10.1101/2020.05.11.054619

Sensorimotor hallucinationsin Parkinson's disease

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Abstract

Hallucinations in Parkinsons disease (PD) are one of the most disturbing non-motor symptoms, affect half of the patients, and constitute a major risk factor for adverse clinical outcomes such as psychosis and dementia. Here we report a robotics-based approach, enabling the induction of a specific clinically-relevant hallucination (presence hallucination, PH) under controlled experimental conditions and the characterization of a PD subgroup with enhanced sensorimotor sensitivity for such robot-induced PH. Using MR-compatible robotics in healthy participants and lesion network mapping analysis in neurological non-PD patients, we identify a fronto-temporal network that was associated with PH. This common PH-network was selectively disrupted in a new and independent sample of PD patients and predicted the presence of symptomatic PH. These robotics-neuroimaging findings determine the behavioral and neural mechanisms of PH and reveal pathological cortical sensorimotor processes of PH in PD, identifying a more severe form of PD associated with psychosis and cognitive decline.

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Bernasconi, F., Blondiaux, E., Potheegadoo, J., Stripeikyte, G., Pagonabarraga, J., Bejr-Kasem, H., Bassolino, M., Akselrod, M., Martinez-Horta, S., Sampedro, F., Hara, M., Horvath, J., Franza, M., Konik, S., Bereau, M., Ghika, J.-A., Burkhard, P. R., Van De Ville, D., Faivre, N., Rognini, G., Krack, P., Kulisevsky, J., Blanke, O.. 2020-05-12. Sensorimotor hallucinationsin Parkinson's disease. https://doi.org/10.1101/2020.05.11.054619

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