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bioRxiv · 10.1101/2020.05.08.085043

Alterations in odor hedonics in the Tg6799 Alzheimer's disease mouse model and the influence of sex

Roberts, E. R.·Dossat, A. M.·del Mar Cortijo, M.·Brundin, P.·Wesson, D. W.
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Abstract

Olfactory impairments, including deficits in odor detection, discrimination, recognition, and changes in odor hedonics are reported in the early stages of Alzheimers disease (AD). Rodent models of AD display deficits in odor learning, detection, and discrimination - recapitulating the clinical condition. However, the impact of familial AD genetic mutations on odor hedonics is unknown. We tested 2-, 4-, and 6-months old 5XFAD (Tg6799) mice in the five-port odor multiple-choice task designed to assay a variety of odor-guided behaviors, including odor preferences/hedonics. We found that 5XFAD mice investigated odors longer than controls, an effect that was driven by 6-months old mice. Interestingly, this effect was carried by females in the 5XFAD group, who investigated odors longer than age-matched males. Upon examining behavior directed towards individual odors to test for aberrant odor preferences, we uncovered that 5XFAD females at several ages displayed heightened preferences towards some of the odors, indicating aberrant hedonics. We observed no impairments in the ability to engage in the task in 5XFAD mice. Taken together, 5XFAD mice, particularly 5XFAD females, displayed prolonged odor investigation behavior and enhanced preferences to certain odors. The data provide insight into hedonic alterations which may occur in AD mouse models, and how these are influenced by biological sex.

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Roberts, E. R., Dossat, A. M., del Mar Cortijo, M., Brundin, P., Wesson, D. W.. 2020-05-10. Alterations in odor hedonics in the Tg6799 Alzheimer's disease mouse model and the influence of sex. https://doi.org/10.1101/2020.05.08.085043

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