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bioRxiv · 10.1101/2020.04.29.067983

Evaluation of 19 antiviral drugs against SARS-CoV-2 Infection

Liu, S.·Lien, C.·Selveraj, P.·Wang, T.
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Abstract

The global pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or 2019-nCoV) has prompted multiple clinical trials to jumpstart search for anti-SARS-CoV-2 therapies from existing drugs, including those with reported in vitro efficacies as well as those ones that are not known to inhibit SARS-CoV-2, such as ritonavir/lopinavir and favilavir. Here we report that after screening 19 antiviral drugs that are either in clinical trials or with proposed activity against SARS-CoV-2, remdesivir was the most effective. Chloroquine only effectively protected virus-induced cytopathic effect at around 30 {micro}M with a therapeutic index of 1.5. Our findings also suggest that velpatasvir, ledipasvir, ritonavir, litonavir, lopinavir, favilavir, sofosbuvir, danoprevir, and pocapavir do not have direct antiviral effect.

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Liu, S., Lien, C., Selveraj, P., Wang, T.. 2020-04-29. Evaluation of 19 antiviral drugs against SARS-CoV-2 Infection. https://doi.org/10.1101/2020.04.29.067983

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