Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)

McCrory, C.; Fiorito, G.; Hernandez, B.; Polidoro, S.; O'Halloran, A. M.; Hever, A.; NiCheallaigh, C.; Lu, A. T.; Horvath, S.; Vineis, P.; Kenny, R. A.

doi:10.1101/2020.04.27.063164

bioRxiv · 10.1101/2020.04.27.063164

Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)

McCrory, C.·Fiorito, G.·Hernandez, B.·Polidoro, S.·O'Halloran, A. M.·Hever, A.·NiCheallaigh, C.·Lu, A. T.·Horvath, S.·Vineis, P.·Kenny, R. A.

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Abstract

The aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. The present study examines the associations of four epigenetic clocks - Horvath, Hannum, PhenoAge, GrimAge - with a wide range of clinical phenotypes, and with all-cause mortality at up to 10-year follow-up in a sample of 490 participants in the Irish Longitudinal Study on Ageing. Results indicate that the GrimAge clock represents a step-improvement in the predictive utility of the epigenetic clocks for identifying age-related decline in an array of clinical phenotypes.

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McCrory, C., Fiorito, G., Hernandez, B., Polidoro, S., O'Halloran, A. M., Hever, A., NiCheallaigh, C., Lu, A. T., Horvath, S., Vineis, P., Kenny, R. A.. 2020-04-28. Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA). https://doi.org/10.1101/2020.04.27.063164

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