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bioRxiv · 10.1101/2020.04.20.051755

Impairments in Hippocampal Place Cell Sequences during Errors in Spatial Memory

Abstract

Theta and gamma rhythms temporally coordinate sequences of hippocampal place cell ensembles during active behaviors, while sharp wave-ripples coordinate place cell sequences during rest. We used a delayed match-to-place memory task to investigate whether such coordination of hippocampal place cell sequences is disrupted when memory errors occur. As rats approached a learned reward location, place cell sequences represented paths extending toward the reward location during correct trials. During error trials, paths coded by place cell sequences were significantly shorter as rats approached incorrect stop locations, with place cell sequences starting at a significantly delayed phase of the theta cycle. During rest, place cell sequences replayed representations of paths that were highly likely to end at the correct reward location during correct but not error trials. The relationship between place cell sequences and gamma rhythms, however, did not differ between correct and error trials. These results suggest that coordination of place cell sequences by theta rhythms and sharp wave-ripples is important for successful spatial memory.

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BibTeXRIS

Zheng, C., Hwaun, E., Colgin, L. L.. 2020-04-23. Impairments in Hippocampal Place Cell Sequences during Errors in Spatial Memory. https://doi.org/10.1101/2020.04.20.051755

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