The Medial Temporal Lobe Supports Mnemonic Discrimination For Event Duration

Abstract

Time has an integral role in episodic memory and previous work has implicated the medial temporal lobe in both representing time and discriminating between similar memory traces. Here we developed a novel paradigm to test mnemonic discrimination for temporal duration, as previous temporal work has largely focused on order or maintaining information over time. Thirty-five healthy, young adults completed a continuous-recognition temporal discrimination task in which participants were tasked with detecting a change of stimulus duration on the order of 0.5 seconds and whole-brain high-resolution fMRI data were acquired during this process. Analyses of behavioral results indicate that participants were successful at detecting whether the stimulus duration changed. Further, fMRI analyses revealed that successful trial performance was associated with differential processes in the left entorhinal and perirhinal cortices. Specifically, the left entorhinal cortex was differentially engaged during encoding trials that preceded Target detection, and the left perirhinal cortex was differentially engaged during successful test phase Target and Lure detections. These findings suggest that the entorhinal cortex is involved in the encoding of temporal context information and that the perirhinal cortex is representing the conjunction of item and context during retrieval.