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bioRxiv · 10.1101/2020.04.11.034603

Cell-Type-Specific Expression of Renin-Angiotensin-System Components in the Human Body and Its Relevance to SARS-CoV-2 Infection

Suryawanshi, H.·Morozov, P.·Tuschl, T.·Muthukumar, T.·tenOever, B. R.·Yamaji, M.·Williams, Z.
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Abstract

We have analyzed the cell-type-specific expression of the renin-angiotensin system (RAS) components across 141 cell types or subtypes as defined by single-cell RNA-seq (scRNA-seq) analysis. ACE2, one of the components of RAS, also facilitates SARS-CoV-2 entry into cells in cooperation with its associated protease TMPRSS2. Therefore, our analysis also contributes to the understanding of SARS-CoV-2 infection, spreading of the virus throughout the body, and potential viral interference with RAS in COVID-19 patients.

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Suryawanshi, H., Morozov, P., Tuschl, T., Muthukumar, T., tenOever, B. R., Yamaji, M., Williams, Z.. 2020-04-11. Cell-Type-Specific Expression of Renin-Angiotensin-System Components in the Human Body and Its Relevance to SARS-CoV-2 Infection. https://doi.org/10.1101/2020.04.11.034603

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