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bioRxiv · 10.1101/2020.04.09.025932

Maternal exposure to the cannabinoid agonist WIN 55,12,2 during lactation induces lasting behavioral and synaptic alterations in the rat adult offspring of both sexes

Scheyer, A. F.·Borsoi, M.·Pelissier-Alicot, A.-L.·Manzoni, O. J.
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Abstract

Consumption of cannabis during pregnancy and the lactation period is a rising public health concern (Scheyer et al., 2019). We have previously shown that exposure to synthetic or plant-derived cannabinoids via lactation disrupts perinatal programming of the gamma-aminobutyric acid trajectory in the prefrontal cortex and early-life behaviors (Scheyer et al., 2020b). Recently, we described lasting behavioral and neuronal consequences of {Delta}9-tetrahydrocannabinol (THC) perinatal exposure via lactation (Scheyer et al., 2020a). Here, we extend upon these findings by testing the effects in offspring of maternal exposure to the synthetic cannabinoid agonist WIN 55,12,2 (WIN). The data demonstrate that rats exposed during lactation to WIN display social, cognitive and motivational deficits at adulthood. These behavioral changes were paralleled by a specific loss of endocannabinoid-mediated long-term depression in the prefrontal cortex and nucleus accumbens, while other forms of synaptic plasticity remained intact. Thus, similarly to THC, perinatal WIN exposure via lactation induces behavioral and synaptic abnormalities lasting into adulthood.

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Scheyer, A. F., Borsoi, M., Pelissier-Alicot, A.-L., Manzoni, O. J.. 2020-04-10. Maternal exposure to the cannabinoid agonist WIN 55,12,2 during lactation induces lasting behavioral and synaptic alterations in the rat adult offspring of both sexes. https://doi.org/10.1101/2020.04.09.025932

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