Systematic Chemogenetic Library Assembly

Canham, S. M.; Wang, Y.; Cornett, A.; Auld, D. S.; Baeschlin, D. K.; Patoor, M.; Skaanderup, P. R.; Honda, A.; Llamas, L.; Wendel, G.; Mapa, F. A.; Aspesi, P.; Labbe-Giguere, N.; Gamber, G. G.; Palacios, D. S.; Schuffenhauer, A.; Deng, Z.; Nigsch, F.; Frederiksen, M.; Bushell, S. M.; Rothman, D.; Jain, R. K.; Hemmerle, H.; Briner, K.; Porter, J. A.; Tallarico, J. A.; Jenkins, J. L.

doi:10.1101/2020.03.30.017244

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bioRxiv · 10.1101/2020.03.30.017244

Systematic Chemogenetic Library Assembly

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Abstract

The assembly of chemogenetic libraries composed of chemical probes provides tremendous value to biomedical research, but requires substantial effort to ensure diversity as well as quality of the contents. We are assembling a chemogenetic library by data mining and crowdsourcing institutional expertise. We are sharing our methodology, lessons learned, and disclosing our current collection of 4186 compounds with their primary annotated gene targets.

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Canham, S. M., Wang, Y., Cornett, A., Auld, D. S., Baeschlin, D. K., Patoor, M., Skaanderup, P. R., Honda, A., Llamas, L., Wendel, G., Mapa, F. A., Aspesi, P., Labbe-Giguere, N., Gamber, G. G., Palacios, D. S., Schuffenhauer, A., Deng, Z., Nigsch, F., Frederiksen, M., Bushell, S. M., Rothman, D., Jain, R. K., Hemmerle, H., Briner, K., Porter, J. A., Tallarico, J. A., Jenkins, J. L.. 2020-04-01. Systematic Chemogenetic Library Assembly. https://doi.org/10.1101/2020.03.30.017244

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