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bioRxiv · 10.1101/2020.03.21.001172

EFFECTS OF BLOOD SUGAR LEVELS, KIDNEY DISEASE AND MEDICATION ON ANAEMIA STATUS OF TYPE 2 DIABETES MELLITUS PATIENTS

Mulavu, M.·Zulu, M.·Sinkala, M.·Munsaka, S.·Okuku, P.·Nkhoma, P.
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Abstract

IntroductionLifestyle-related diseases like type 2 diabetes mellitus, have emerged as a significant public health problem due to rapid urbanization and industrialization. In 2018, the prevalence of type 2 diabetes mellitus was estimated to be 500 million cases worldwide and was comparable between high- and low-income countries. Diabetes leads to multiple complications, including end-stage renal disease, cardiovascular disease, infection, and death. Anaemia in diabetic individuals has severe adverse effects on the quality of life and is associated with disease progression. A cross-sectional study was conducted that included 101 participants. The study aimed to determine the prevalence of anaemia and kidney disease and their interplay with medication and/or blood glucose levels in T2D patients. Resultsseventy-one per cent of participants were females. Majority of patients 62% were on Insulin, 30% on metformin, 7% on a combination of metformin and glimepiride and 1% on glimepiride. Ninety-five (94%) of the participants were HIV negative. The prevalence of anaemia among the participants was 23% out of which 56% had moderate anaemia, and 44% had mild anaemia. Twenty-one per cent (21%) of the participants had high creatinine levels signifying impaired kidney function or kidney disease. Anaemia was significantly associated with kidney function, fasting blood glucose and use of metformin; p = 0.042 beta = 2.5, p = 0.025 beta = 2.7 and p = 0.040 beta = -2.5 respectively. ConclusionThe study found the prevalence of anaemia of 23%, which was of moderate public health concern. Also, the prevalence of kidney disease was high in patients with Type 2 Diabetes Mellitus. It also found that kidney disease and high blood glucose levels increase the chances of developing anaemia. However, we found that metformin had a protective role against the development of anaemia in Type 2 Diabetes Mellitus patients.

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Mulavu, M., Zulu, M., Sinkala, M., Munsaka, S., Okuku, P., Nkhoma, P.. 2020-03-23. EFFECTS OF BLOOD SUGAR LEVELS, KIDNEY DISEASE AND MEDICATION ON ANAEMIA STATUS OF TYPE 2 DIABETES MELLITUS PATIENTS. https://doi.org/10.1101/2020.03.21.001172

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